Ecological and Biochemistry

1. Isolation And Identification Of Insect Repelling Compounds From Indigenous Plants

Chemical analysis of selected indigenous plants and their biological activity.
Identification of naturally occurring mosquitoes/ticks repellents from plants.
 Exploring the chemical diversity of Pakistani plants focusing on the insect repellent properties.
Project Members
  • Dr Muhammad Azeem
  • 2. Bioactive Molecules From Pakistani Flora For The Ecological Control Of Aedes Mosquitoes

    Mosquitoes are one of the severe domestic pest insects in major parts of the world. They not only
    are the vectors of deadly diseases like malaria, dengue, zika and chikungunya but also cause
    itching nuisance on biting to their subjects. Dengue fever is an endemic in large part of world is
    vectored by mosquito species Aedes aegypti. Since the last few decades, the people living in rural
    and urban area of South Asian countries are at high risk of dengue fever and chikungunya due to
    high density out breaks of this mosquito species. Insecticides spray is the common method to
    control mosquitoes’ population that not only leaves adverse effects on the environment but also
    creating resistance in this severe pest. There is an urgent need to explore low-cost and indigenous
    available sources for the ecological control of mosquitoes. The lower Himalaya region of Pakistan is
    rich in diversified type of flora that never been systematically investigated for insecticidal or
    mosquito repellent bio-activities. Essential oils and solvents extracts of selected plants (Asterasce,
    Lamiaceae, Myrtaceae and Rutaceae families) growing at different altitudes in the Himalaya region
    of Pakistan will be investigated for Aedes mosquito larvicidal, insecticidal and repellent activities.
    The bio-assay guided fractionation will be employed to isolate bio-active fractions and pure
    compounds. GC-MS will be used to separate, identify and quantify molecules from bio-active plant
    extracts and fractions. The unknown pure compounds will be identified by using spectroscopic
    techniques NMR, MS, UV-VIS and FTIR. The outcome of this project will be an enhanced
    knowledge of the diversity of plant species growing at different altitude of lower Himalaya region
    Pakistan and the chemical composition of their secondary metabolites. We expect to find potent
    compounds or fractions having larvacidal, insecticidal and mosquito repelling activities.

    Project Funding
     Funding Body Funds
    1 International Foundation for Science, Sweden no logo 1300000 Rs

    Project Members
  • Dr Muhammad Azeem