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Faculty Profile

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Dr. Asim Ali

Assistant Professor
Area of Interest: Human Genetics, Reproductive Biology
Email: asimali@cuiatd.edu.pk
Phone: +92-992-383591-5
 
Academics/ Degrees
  • Ph.D - Genetics (2019), Molecular and Cell Genetics Lab, School of Life Sciences, University of Science and Technology of China.
  • MS - Biotechnology (2014), Department of Biotechnology, COMSATS University Islamabad, Abbottabad Campus.
  • BS (Hons) - Microbiology (2012), Department of Microbiology, Hazara University Mansehra.
 
Journal Publications
1. Ahsanullah Unar,Ali A Determination of Electrolytes and Trace Elements in Biological Samples from Patients with Altered Semen Parameters: a Correlational Analysis, Biological Trace Element Research, 2024
2. Ali A,M.Ali,Shah B A novel NPHP4 homozygous missense variant identified in infertile brothers with multiple morphological abnormalities of the sperm flagella, Journal of Assisted Reproduction and Genetics, 2023
3. Qinghua Shi,Ali A Biallelic mutations in RNA-binding protein ADAD2 cause spermiogenic failure and non-obstructive azoospermia in humans, Human Reproduction Open, 2023
4. Qinghua Shi,Ali A Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility, Developmental Biology, 2023
5. Hassan Imran Afridi,Ali A Effect Of Lead On The Skin And Health Of Female Dermatitis Patients Through Cosmetics., Journal of Ayub Medical College Abbottabad-Pakistan, 2023
6. Ahsanullah Unar,Ali A Essential trace elemental levels (Zinc, Iron and Copper) in the biological samples of referent and different types of drug abuse patients, Bioscience Research, 2022
7. Ali A FertilityOnline: A Straightforward Pipeline for Functional Gene Annotation and Disease Mutation Discovery, Genomics, Proteomics and Bioinformatics, 2022
8. Qinghua Shi,Ali A Novel Loss-of-Function Mutations in DNAH1 Displayed Different Phenotypic Spectrum in Humans and Mice, Frontiers in Endocrinology, 2021
9. Ali A MeiosisOnline: a manually curated database for tracking and predicting genes associated with meiosis, Frontiers in Cell and Developmental Biology, 2021
10. Qinghua Shi,Ali A Exonuclease 5 is dispensable for meiotic progression and male fertility in mouse, Gene, 2021
11. Suixing Fan,Qinghua Shi,Ali A Homozygous mutations in C14orf39/SIX6OS1 cause non-obstructive azoospermia and premature ovarian insufficiency in humans, American Journal of Human Genetics, 2021
12. Yuying Jiao,Qinghua Shi,Ali A A TOP6BL mutation abolishes meiotic DNA double-strand break formation and causes human infertility, Science Bulletin, 2020
13. Qinghua Shi,Ali A Novel loss‐of‐function variants in DNAH17 cause multiple morphological abnormalities of the sperm flagella in humans and mice, Clinical Genetics, 2020
14. Sarfraz Shafiq,Ali A The Interplay between Toxic and Essential Metals for Their Uptake and Translocation Is Likely Governed by DNA Methylation and Histone Deacetylation in Maize., International Journal of Molecular Sciences, 2020
15. H Muhammad,Ali A Diagnosis of Idiopathic Primary Infertility in a Consanguineous Infertile Family using Clinical and Molecular Cytogenetic Techniques, Genetics and Molecular Research, 2020
16. Beibei Zhang,Qinghua Shi,Ali A A DNAH17 missense variant causes flagella destabilization and asthenozoospermia, Journal of Experimental Medicine, 2019
17. Sarfraz Shafiq,Ali A,Y.Sajjad Lead, Cadmium and Zinc Phytotoxicity Alter DNA Methylation Levels to Confer Heavy Metal Tolerance in Wheat., International Journal of Molecular Sciences, 2019
18. Dong-Qing Wei,Ali A Immunoinformatics approaches to explore Helicobacter Pylori proteome (Virulence Factors) to design B and T cell multi-epitope subunit vaccine, Scientific Reports, 2019
19. Yubin Xie,Qinghua Shi,Ali A The testis-specifically expressed Dpep3 is not essential for male fertility in mice, Gene, 2019
20. Xiaohua Jiang,Qinghua Shi,Ali A Npat‐dependent programmed Sertoli cell proliferation is indispensable for testis cord development and germ cell mitotic arrest, FASEB Journal, 2019
21. Teka Khan,Qinghua Shi,Ali A Whole exome sequencing identifies a novel dominant missense mutation underlying leukonychia in a Pakistani family, Journal of Human Genetics, 2018
22. Ali A,Qinghua Shi IsopiRBank: a research resource for tracking piRNA isoforms, Database, 2018
23. Hao Yin,Qinghua Shi,Ali A A homozygous FANCM frameshift pathogenic variant causes male infertility, Genetics in Medicine, 2018
24. Qinghua Shi,Ali A MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice, PLoS genetics, 2018
25. Manan Khan,Qinghua Shi,Ali A The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice, Scientific Reports, 2018
26. Yu-Sheng Liu,Ali A Feasibility analysis of treating severe intrauterine adhesions by transplanting menstrual blood-derived stem cells, International journal of molecular medicine, 2018
27. R.Ahmad,Ali A Cystatin genes identification and antibacterial activity in medicinal plants used against clinical pathogens., SYLWAN, 2018
28. Qinghua Shi,Ali A Anaconda: AN automated pipeline for somatic COpy Number variation Detection and Annotation from tumor exome sequencing data, BMC bioinformatics, 2017
29. Shi Yin,Qinghua Shi,Ali A Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels, Development, 2017
 
Profile/Bio
  • April, 2022 till now: Assistant Professor, Department of Biotechnology, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
  • July, 2019 to November, 2020: Postdoctoral Research Fellow at Hefei National Laboratory for Physical Sciences at the Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Diseases, School of Life Sciences, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China
 
 
Research Interests
  • Genetic Disorders
  • Reproduction Biology
  • Human Infertility
  • Cytogenetics
 
Awards
  • Awarded Chinese Government Scholarship for Ph.D studies in China.
  • Reviewer of the Journal “Briefings in Bioinformatics”.

 
Research Projects

  •         C11ORF80 frameshift mutation results in azoospermia and primary ovarian insufficiency in Pakistani consanguineous family- Funded by National Science Foundation of China, 2018-2021. (Co-Principal Investigator)

  •          RNA Splicing factor SF1 homologous frameshift result in spermatogenic abnormalities in human and mouse - Funded by National Science Foundation of China 2017-2019. (Co-Principal Investigator)