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Faculty Profile

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Dr Zia Uddin

Assistant Professor
Area of Interest: Pharmacognosy/ Drugs discovery from natural products
Email: ziauddin@cuiatd.edu.pk
Phone: 0992-383591-5
 
Academics/ Degrees

  • Postdoc, Institute of Agriculture and Life Science, GNU, South Korea, 2018.
  • Ph.D, Gyeongsang National University, South Korea, 2017.
  • M.S, Gyeongsang National University, South Korea, 2014.
  • Pharm.D, University of Malakand, KPK, Pakistan, 2010.

 
Journal Publications
1. Zia Uddin Streptomyces sp. from desert soil as a biofactory for antioxidants with radical scavenging and iron chelating potential , BMC Microbiology, 2024
2. Zia Uddin Syringic acid improves cyclophosphamide-induced immunosuppression in a mouse model, Biochemical and Biophysical Research Communications, 2024
3. Zia Uddin Integrative Investigation and Prioritization of Candidate Genes PTGS-2 and VEGF: Unveiling their Interaction with Celecoxib for Targeted Therapeutic Applications. , Precision Medicine Communications, 2023
4. Zia Uddin Assessment of Human Interleukin-24 Expression in Thalassemic Patients and Investigation of Current Prescription Pattern in Thalassemia. , Currents In Pharmaceutical Research, 2023
5. Zia Uddin Evidence-Based Prioritization and Scoring of Genomic Loci Interacting with Pioglitazone Therapeutic Response in Diabetic Patients, Precision MedicineCommunications, , 2022
6. Dr. Imran Ullah,Ikram Muhammad,Zia Uddin Targeted Inhibition of Protein Tyrosine Phosphatase 1B by Viscosol Ameliorates Type 2 Diabetes Pathophysiology and Histology in Diabetic Mouse Model, BioMed Research International, 2022
7. Zia Uddin Hesperetin activated SIRT1 neutralizes cadmium effects on the early bovine embryo development, Theriogenology, 2022
8. Zia Uddin PEGylated-Protamine Letrozole Nanoparticles: A Promising Strategy to Combat MCF-7 Human Breast Cancer Cells, BioMed Research International, 2022
9. Zia Uddin Carveol a Naturally-Derived Potent and Emerging Nrf2 Activator Protects Against Acetaminophen-Induced Hepatotoxicity, Frontiers in Pharmacology, 2021
10. Zia Uddin,U. Rashid Evaluation of Cholinesterase Inhibitory Potential of Different Genotypes of Ziziphus nummularia, Their HPLC-UV, and Molecular Docking Analysis, Molecules , 2020
11. Zia Uddin Evaluation of neuroprotective and antiamnesic effects of Elaeagnus umbellata Thunb. On scopolamine-induced memory impairment in mice, BMC Complementary Medicine and Therapies, 2020
12. Zia Uddin Hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity in rats, Immunopharmacology and Immunotoxicology, 2020
13. Zia Uddin Highly potent bacterial neuraminidase inhibitors, chromenone derivatives from Flemingia philippinensis, International Journal of Biological Macromolecules, 2019
14. Zia Uddin Bacterial neuraminidase inhibition by phenolic compounds from Usnea longissima, South African Journal of Botany , 2019
15. Zia Uddin Antioxidant Activities of Phenolic Metabolites from Flemingia philippinensis Merr. et Rolfe and Their Application to DNA Damage Protection, Molecules, 2018
16. Zia Uddin Competitive Neutrophil Elastase Inhibitory Isoflavones from the Roots of Flemingia philippinensis, Bioorganic Chemistry, 2018
17. Zia Uddin Isolation and Characterization of Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Polyphenolic Compounds From Dodonaea viscosa and Their Kinetic Analysis, Frontiers in Chemistry, 2018
18. Zia Uddin Caged xanthones displaying protein tyrosine phosphatase 1B (PTP1B) inhibition from Cratoxylum cochinchinense, Bioorganic Chemistry, 2018
19. Zia Uddin Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization, Bioorganic & Medicinal Chemistry, 2018
20. Zia Uddin Phytochemical profile and angiotensin I converting enzyme (ACE) inhibitory activity of Limonium michelsonii Lincz, Journal of Natural Medicen, 2017
21. Zia Uddin Polydatin improves the developmental competence of bovine embryos in vitro via induction of sirtuin 1 (Sirt1), Reproduction, Fertility and Development, 2017
22. Zia Uddin 2-Methoxystypandrone improves in vitro-produced bovine embryo quality through inhibition of IKBKB, Theriogenology, 2017
23. Zia Uddin Inhibition of protein tyrosine phosphatase (PTP1B) and a-glucosidase by geranylated flavonoids from Paulownia tomentosa, Journal of Enzyme inhibition and Medicinal Chemistry, 2017
24. Zia Uddin Visconata: A rare flavonol having long chain fatty acid from Dodonaea viscosa which inhibits Human neutrophil elastase (HNE), Tetrahedron Letters, 2017
25. Zia Uddin Prenylated Flavonoids from Epimedium koreanum Nakai and their Human Neutrophil Elastase Inhibitory Effects, Records of Natural Products, 2017
26. Zia Uddin Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism., Bioorganic & Medicinal Chemistry, 2017
27. Zia Uddin Potent bacterial neuraminidase inhibitors, anthraquinone glucosides from Polygonum cuspidatum and their inhibitory mechanism., Journal of Ethnopharmacology, 2016
28. Zia Uddin Ethylene Induced a High Accumulation of Dietary Isoflavones and Expression of Isoflavonoid Biosynthetic Genes in Soybean (Glycine max) Leaves, Journal of Agricultural and Food Chemistry, 2016
29. Zia Uddin Human Neutrophil Elastase Inhibitory Alkaloids from Chelidonium majus L., Journal of Applied Biological Chemistry, 2015
 
 
 
Profile/Bio

  • July.2018 till now: Assistant Professor, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan
  • August.2017 to June. 2018: Postdoctoral Research Fellow, Institute of Agriculture and Life Science, GNU, South Korea.
  • March. 2015 to July. 2017: Researcher, IALS, Gyeongsang National University, South Korea.

 
 
Research Interests
  • Activity guided fractionation and purification of targeted active constituents.
  • Structural characterization and complete identification of lead molecules.
  • Evaluation of biological activities on enzymes based assays.
  • Structure activity relationship (SAR) study of potent molecules.
  • Enzymes inhibition and their detailed Kinetic study, mechanisticbehaviors, and enzyme-inhibitor interaction.
  • Quantitative and qualitative analysis of secondary metabolites.
  • Metabolite farming, monitoring the flow of secondary metabolites during different growth stages.