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Dr. Jamshed Iqbal, TI, FRSC, FPAS

  /  Dr. Jamshed Iqbal, TI, FRSC, FPAS
Professor, Chemistry
Specialization:

Medicinal Chemistry, Molecular
Biology, Pharmacology, Computer Aided Drug Design


Email: drjamshed@cuiatd.edu.pk
Phone: +92-992-383591-5

Academics/ Degrees:

  • Postdoc           2009-2010       Chinese Academy of Sciences, China
  • Postdoc           2005-2009       University of Bonn, Germany
  • PhD                 2005                University of Bonn, Germany
  • MSc                 2000                University of Strathclyde,
    Glasgow, UK
  • MSc                 1996                Bahauddin Zakariya University,
    Multan
  • MPhil              1999                 Quaid-i-Azam University,
    Islamabad

 

 

 

 

 

 
 
Journal Publications
 
Conference Publications
 
BOOKS AND BOOK CHAPTERS
 
Profile/Bio
  • Professor
                        2013 till date               CUI Abbottabad
  • Associate
    Professor     2007 – 2013                COMSATS IIT, Abbottabad
  • Lecturer
                          1999- 2000                  Islamia University
    Bahawalpur
 
Associations
  • Fellow of Royal Society of Chemistry (FRSC)
  • Fellow of the Pakistan Academy of Science (FPAS) 
  • Fellow of the Chemical Society of Pakistan (FCSP)
  • Member of Royal Pharmaceutical Society of Great Britain (RPSGB) 
  • Member of German Pharmaceutical Society (DPhG) 
  • Member of Pakistan Society for Biochemistry and Molecular Biology (PSBMB)
 
Research Interests
  • Synthesis of agonists and/or
    antagonists of purinergic receptors; enzymes inhibitors
  • Cloning and expression of purinergic
    receptors (G protein-coupled receptors and ligand-gated ion channels
    receptors).
  • Cloning and expression of ectonucleotidases,
    carbonic anhydrases, ALRs enzymes
  • Molecular docking and dynamics simulation of receptors and
    enzymes

 

 

 

 
 
Awards

AWARDS/APPRECIATIONS

  • HEC Outstanding Research Award for 2021 in the field of Life Sciences, Biological Sciences, Health Sciences, Pharmacy, Agriculture, or Veterinary Sciences
  • Prestigious Fellow of Royal Society of Chemistry (FRSC) conferred by the Royal Society of Chemistry, United Kingdom.
  • Pakistan Academy of Sciences Gold Medal for 2017.
  • Tamgha-i-Imtiaz, 2012, Pakistan’s highest civilian decorations awarded by president of Pakistan.
  • Best Researcher Award at Campus Level, COMSATS University Islamabad, Abbottabad Campus, Pakistan, 2015.
  • Best Researcher Award at Campus Level, COMSATS University Islamabad, Abbottabad Campus, Pakistan, 2020.
  • Research Productivity Award for 2011, 2012, 2013, 2014, 2015, 2016, 2017 & 2018 by COMSATS Institute of Information Technology.
  • Research Productivity Award for 2013, 2014, 2015, 2016 & 2017 by Pakistan Council for Science and Technology (PCST), Islamabad. In 2015 and 2016, the award was in the highest category “A”. However, in 2017, Prof. Iqbal won the same award in category “A” having 10.82 score by getting 21st position out of 2896 candidates in various disciplines throughout the Country. Moreover, Prof. Iqbal got 2nd position in Productive Scientists of Pakistan (PSP) out of 2631 Pakistani Scientist in various disciplines among the country.
  • Most Cited Paper 2006-2009 Award from Elsevier Publishers, Christa E. Müller, Jamshed Iqbal, Younis Baqi, Herbert Zimmermann, Anita Röllich, Holger Stephan. “Polyoxometalates – a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorganic & Medicinal Chemistry Letters (2006) 16 (23), 5943-5947
  • Pakistan 50th Anniversary Fund Scholarship for M.Sc. at University of Strathclyde, Glasgow, UK.
  • DAAD, STIBET Scholarship for Postdoc at University of Bonn, Germany.
  • CAS Research Fellowship for International Young Researchers. Research Fellow (2009-2010): Dalian Institute of Chemical Physics, CAS, 457 Zhongshan Road, 116023, Dalian, Chinese Academy of Sciences.
  •  International Young Researchers award given by President of Chinese Academy of Sciences, China.
  • Merit Scholarship (University Grants Commission of Pakistan) for M.Phil. studies at Quaid-i-Azam University, Islamabad.
  • Travel grant from GlaxoSmithKline for participation in 8th International Symposium on Adenosine and Adenine Nucleotides. University of Ferrara, Italy, May 24 – 28, 2006.
  • Travel grant from GlaxoSmithKline for Second Joint Italian-German Purine Club Meeting Leipzig, Germany, September 12-15, 2007.
  • Travel grant from GlaxoSmithKline for Microscale bio-separations and methods for systems biology, Berlin, Germany, March 9-13, 2008 (MSB 2008).
  • Travel grant from GlaxoSmithKline for Purines 2008 Meeting 29th June – 2nd July 2008, Copenhagen, Denmark. 
 

SEMINARS/ WORKSHOPS DELIVERED

  • Prof. Dr. Jamshed Iqbal, Invited Lecture 18th Symposium on Purine and Pyrimidine Metabolism in Man orginzed by “The Purine and Pyrimidine Society” from 12th to 14th of June 2019 in Lyon, France
  •  Prof. Dr. Jamshed Iqbal, Keynote Speaker in International Conference on Chemical Sciences, organized by Department of Chemistry Quaid i Azam University, Islamabad, during April 24-26, 2019.
  • Prof. Dr. Jamshed Iqbal, Keynote Speaker in 3rd International Conference on Recent Innovations in Pharmaceutical Sciences (ICRIPS-2019), March 13-14, 2019, Riphah International University, Islamabad, Pakistan.
  • Prof. Dr. Jamshed Iqbal, Keynote Speaker in 1st International Conference on “Advancements in Biotechnology & Biocomputing” organized by Department of Biological Sciences, International Islamic University, Islamabad during 7-9 February, 2019.
  • Prof. Dr. Jamshed Iqbal, Keynote Speaker in 1st Annual Conference on “The Current Usage of Nanotherapeutics & Biodrugs” organized by Department of Biological Sciences, International Islamic University, Islamabad during 12-13 December, 2018.
  • Prof. Dr. Jamshed Iqbal, Invited lecture in International Conference entitled “Purines 2018 International – Basic and translational science on purinergic signaling and its components for a healthy and better world” during 19-22 June, 2018 in Brazil.
  • Prof. Dr. Jamshed Iqbal, Plenary talk in two-day National conference on “Recent Advancements in Pharmaceutical Sciences: Innovative Drug Research for Better Cure” during 7-8 March, 2018, organized by College of Pharmacy, University of Sargodha, Pakistan.
  • Prof. Dr. Jamshed Iqbal, Invited speaker at “3rd International Health Trigon Summit, Inter-Professional Cooperation in Pharmacotherapy” 2018 held during 17-18th April, 2018 organized by The University of Lahore, Pakistan.
  • Prof. Dr. Jamshed Iqbal, Plenary speaker in International Conference on Chemical and Pharmaceutical Sciences: Recent Approaches in Research & Applications, to held on 17-19 January, 2018 at Forman Christian College (A Chartered University) Lahore, Pakistan.
  • Prof. Dr. Jamshed Iqbal, Plenary speaker in 1st International Conference on Advances in Drug Discovery and Development” to held on 3-5 January, 2018 at NARC, Islamabad, Pakistan.
  • Prof. Dr. Jamshed Iqbal, Plenary speaker in 2nd International Conference on Recent Innovations in Pharmaceutical Sciences (ICRIPS-2017), November 15-16, 2017, Riphah International University, Islamabad, Pakistan.
  • Prof. Dr. Jamshed Iqbal, Plenary speaker in three-day international conference on “Current Research in Chemical & Pharmaceutical Sciences” January 18-20, 2017, Forman Christian College (A Chartered University) Lahore, Pakistan.
  • Prof. Dr. Jamshed Iqbal, Plenary speaker in 1st Biennial Conference on “New Horizons in Drug Discovery and Pharmaceutical Scieces” December 15, 2016, Abbottabad University of Science and Technology, Abbottabad.
  • Prof. Dr. Jamshed Iqbal, Invited Speaker in International Symposium on “Modern Strategies in Drug Discovery & Vaccine Design” December 2-3, 2016 at Lahore University of Management Sciences, Lahore.
  • Prof. Dr. Jamshed Iqbal, 1st International Conference on “Recent Innovations in Pharmaceutical Sciences”, March 3- 5, 2015, Riphah International University, Islamabad, Pakistan.
  • Prof. Dr. Jamshed Iqbal, International Conference on “Exploring New Avenues In Medicinal Chemistry: Opportunities And Challenges” January 21-23, 2015, Forman Christian College (A Chartered University) Lahore, Pakistan.
  • Prof. Dr. Jamshed Iqbal, Seminar on “Enzyme Inhibitors as Drug Targeting Challenges and Opportunities” November 28, 2014, Riphah International University, Islamabad, Pakistan.
  • Dr. Jamshed Iqbal, 14th Asian Symposium On Medicinal Plants, Spices and other Natural Products (ASOMPS), December 9-12, 2013, H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
  • Dr. Jamshed Iqbal, 11th Shokat Khanam Cancer Symposium, November 9-11, 2012, Lahore, Pakistan.
  • Dr. Jamshed Iqbal, International Scientific Spring (ISS) -2012 at National Centre for Physics, Islamabad from March 5-9, 2012 and Workshop on Nano Technology on March 10, 2012.
  • Jamshed Iqbal, Rabia Raza, Abdul Matin, Sundas Sarwar, Maria Barsukova-Stuckart, Masooma Ibrahim, Ulrich Kortz. Polyoxometalates as potent and selective inhibitors of alkaline phosphatases with profound anticancer and amoebicidal activities. 11th Shokat Khanam Cancer Symposium, November 9-11, 2012, Lahore, Pakistan.
  • Rabia Raza, Jamshed Iqbal, Abdul Matin, Sundas Sarwar, Maria Barsukova-Stuckart, Masooma Ibrahim, Ulrich Kortz, Polyoxotungstates as inhibitors of cancer regulating enzymes. 11th Shokat Khanam Cancer Symposium, November 9-11, 2012, Lahore, Pakistan.
  • Dr. Jamshed Iqbal, 9th International and 21st national Chemistry Conference, March 14-16, 2011, University of Karachi, Karachi, Pakistan.
  • Dr. Jamshed Iqbal, 9th International and 21th National Chemistry Conference, March 14-16, 2011, Jointly organized by H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences and Department of Chemistry, University of Karachi, Karachi, Pakistan.
  • Rabia Raza and Jamshed Iqbal, Development of enzyme immobilized micro-assay in capillary electrophoresis for characterization and inhibition studies of alkaline phosphatase. 9th International and 21st national Chemistry Conference, March 14-16th, 2011. University of Karachi, Karachi, Pakistan.
  • Miriam Schlenk, Minka Paskaleva, Jamshed Iqbal, Jürgen Gäb, Michael Gütschow, Christa E. Müller. Benzothiazinones – a new class of potent A1-adenosine receptor antagonists. DPhG-Jahrestagung in Braunschweig, 2010 Germany.
  • Jamshed Iqbal and Christa E. Müller. High-sensitivity capillary electrophoresis for monitoring of ecto- purine nucleoside phosphorylase and ecto-adenosine deaminase reactions by large-volume sample stacking. Asia-Pacific International Symposium on Lab on chip. Shanghai, 2009, China.
  • Sabrina Gollos, Fabian Heisig, Sven Jan Freudenthal, Andrea Behrenswerth, Jamshed Iqbal, Ralf Brune, Markus Sauer, Christa E. Müller. New Fluorescent-Labeled adenosine receptor ligands. Purinergic Receptors: New Frontiers for Novel Therapies, Third Joint Italian-German Purine Club Meeting, July 17-20, 2009 Camerino, Italy.
  • Younis Baqi, Stefanie Weyler, Hillmann, Petra, Umbach, Frank, Jamshed Iqbal, Kaulich, Marko, Christa E Müller. Anthraquinones: combinatorial synthesis and structure-activity relationships as non-nucleotide-derived P2Y2 receptor antagonists. Purines 2008 Meeting June 29 – July 2, 2008, Copenhagen, Denmark.
  • Jamshed Iqbal, Younis Baqi, Stefanie Weyler, Herbert Zimmermann, Christa E. Müller. Anthraquinones: structure-activity relationships as inhibitors of ecto-nucleoside triphosphate diphospho-hydrolases (E-NTPDases). Purines 2008 Meeting June 29 – July 2, 2008, Copenhagen, Denmark.
  • Jamshed Iqbal, Aileen F. Knowles, Christa E. Müller. Ecto-nucleoside triphosphate diphosphohydrolase (NTPDase2) immobilized on a polyacrylamide-coated capillary: on-line monitoring of the enzymatic reaction and screening of inhibitors by capillary. Microscale bioseparations and methods for systems biolog, Berlin, Germany, March 9-13, 2008.
  • Christa E. Müller, Andreas Brunschweiger, Younis Baqi, Sang-Yong Lee, Jamshed Iqbal, Herbert Zimmermann. Development of Ecto-5’-nucleotidase inhibitors as potential new anti-cancer drugs. XXth International Symposium on Medicinal Chemistry EFMC-ISMC 2008 Vienna, Austria, August 31-September 4, 2008.
  • Andreas Brunschweiger, Jamshed Iqbal, Mercedes N. Munkonda, Sang-Yong Lee, Herbert Zimmermann, Christa E. Müller. Synthesis and characterization of nucleotide mimetics as inhibitors of ecto-5’-nucleotidase and NTPDase1. Deutschen Pharmazeutischen Gesellschaft, Bonn, Germany, October 8-11, 2008.
  • Jamshed Iqbal, Younis Baqi, Stefanie Weyler, Herbert Zimmermann, Christa E. Müller. Anthraquinones: structure-activity relationships as inhibitors of ecto-nucleoside triphosphate diphospho­hydrolases (E-NTPDases). Deutschen Pharmazeutischen Gesellschaft, Bonn, Germany, October 8-11, 2008.
  • Younis Baqi, Stefanie Weyler, Hillmann Petra, Frank Umbach, Jamshed Iqbal, Kaulich Marko, Christa E. Müller. Anthraquinones: combinatorial synthesis and structure-activity relationships as non-nucleotide-derived P2Y2 receptor antagonists. Deutschen Pharmazeutischen Gesellschaft, Bonn, Germany, October 8-11, 2008.
  • Anne Lehr, Younis Baqi, Herbert Zimmermann, Jamshed Iqbal, Christa E. Müller. Testing of novel Ar (Alk)ylaminoanthraquinone derivatives as inhibitors of Ecto-5’-nucleotidase. Deutschen Pharmazeutischen Gesellschaft, Bonn, Germany, October 8-11, 2008.
  • Sabrina Gollos, Fabian Heisig, Sven J. Freudenthal, Jamshed Iqbal, Ralf Brune, Markus Sauer, Christa E Müller. A Simple route to new, functionalized Bodipy Derivatives. Deutschen Pharmazeutischen Gesellschaft, Bonn, Germany, October 8-11, 2008.
  • Andreas Brunschweiger, Jamshed Iqbal, Mercedes N. Munkonda, Jean Sévigny, Aileen F. Knowles.; Christa E. Müller. Synthesis and structure-activity relationships of 5′-substituted uridine and adenosine derivatives as Ecto-5′-nucleotidase inhibitors. Second Joint Italian-German Purine Club Meeting, Leipzig, Germany, September 12-15, 2007.
  • Miriam Fast, Jamshed Iqbal, Herbert Zimmermann, Jean Sévigny, Christa E. Müller. Capillary electrophoresis-based nano-scale assays for monitoring ecto-5’-nucleotidase activity and inhibition in preparations of recombinant enzyme and melanoma cell membranes. Second Joint Italian-German Purine Club Meeting Leipzig, Germany, September 12-15, 2007.
  • Jamshed Iqbal, Jean Sévigny, Christa E. Müller. A novel, highly sensitive capillary electrophoresis method for monitoring ecto-nucleotide pyrophosphatases. Second Joint Italian-German Purine Club Meeting Leipzig, Germany, September 12-15, 2007.
  • Christa E. Müller, Jamshed Iqbal, Younas Baqi. Kapillarelektrophorese-Nano-Assays in der Wirkstofftestung. GIT LABOR-FACHZEITSCHRIFT  2006, 10, 897-900.
  • Jamshed Iqbal, 8th International Symposium on Adenosine and Adenine Nucleotides, May 24-28, 2006, University of Ferrara, Italy,
  • Christa E. Müller, Jamshed Iqbal, Younas Baqi. Capillary electrophoresis nano-assays Novel in vitro screening methods in the search for future drugs. Screening – Trends in Drug Discovery 2006, 4, 26-28.
  • Jamshed Iqbal, Herbert Zimmermann, Christa E. Müller. Development of a novel, automated method for the characterization and screening of NTPDase inhibitors by in-capillary enzymatic microreaction. Purinergic Signalling 2006, 2, 170-171.
  • Andreas Brunschweiger, Jamshed Iqbal, Mercedes N. Munkonda, Jean Sévigny, Aileen F. Knowles. Christa E. Müller. Development and structure-activity relationship of ectonucleotidase inhibitors. Purinergic Signalling 2006, 2, 170.
  • Younis Baqi, Jamshed Iqbal, Herbert Zimmermann, Anita Röllich, Holger Stephan, Christa E. Müller. Polyoxometalates – discovery of a new class of ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. 3rd Summer School Medicinal Chemistry at the University of Regensburg. “Medicinal Chemistry: Molecular Recognition – Ligand Receptor Interactions”. University of Regensburg, Regensburg, Germany, September 25-27, 2006.
  • Younis Baqi, Jamshed Iqbal, Christa E. Müller. Polyoxometalates – a new class of ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Graduiertenkolleg 804 Analyse von Zellfunktionen durch kombinatorische Chemie und Biochemie. Bonn-Aachen International Center For Information Technology B-IT. University of Bonn, Bonn, Germany, October 20, 2006. 
  • Emmerling, F.; Kraus. W. Iqbal, J.; Müller, C.E.; Röllich, A.; Stephan, H.; Polyoxotungstates as potent inhibitors for ecto-nucleotidases. 37th International Conference of Coordination Chemistry. Cape Town, South Africa, 13-18th August 2006.
  • Jamshed Iqbal, Christa E. Müller. Development of a novel, capillary electrophoresis based method for the screening of potential adenosine kinase inhibitors. 14th Camerino-Noordwijkerhout Symposium “Ongoing Progress in the Receptor Chemistry” University of Camerino, Camerino, Italy, September 7-11, 2003.
  • Jamshed Iqbal, “Medicinal Chemistry and Pharmacology of Purinergic Receptors” September 11-13, 2003, University of Camerino, Camerino, Italy.
  • Jamshed Iqbal, 14th Camerino-Noordwijkerhout Symposium “Ongoing Progress in the Receptor Chemistry” September 7-11, 2003, University of Camerino, Camerino, Italy.
  • Jamshed Iqbal, Muhammad Ikram. Determination of lead in roadside soil, gasoline by AAS and UV-Vis spectrophotometer and development of micro emulsion method for the determination of lead in gasoline. Quaid-i-Azam University, Islamabad, Pakistan on October 28-30, 1999.
  • Jamshed Iqbal, 4th DAAD follow-up Seminar (Chemistry) April 29-May 01, 1999, Quaid-i-Azam University Islamabad, Pakistan.
 
Research Projects

RESEARCH
PROJECTS:

  • Research project titled, “Ionic Liquid Mediated
    Multicomponent Reactions (MCRs) for Synthesis of Biologically Active
    Heterocyclic Compounds: Synthesis, Structural Elucidation and Evaluation of
    Biological Activities Targeting Neurodegenerative Diseases” of Rs 3.7 million,
    by Higher Education Commission of Pakistan (HEC) under National Research
    Program for Universities (NRPU). [Project No.
    7676/Punjab/NRPU/R&D/HEC/2017]. Year awarded: 2018. (Co-PI)
  •  Research project titled, “Synthesis of Novel
    Sulfonamide Derivatives as Inhibitors of Ectonucleotidases” of 3.9 Million Rs.,
    by Higher Education Commission of Pakistan (HEC) under National Research
    Program for Universities (NRPU) [project No. 20-3133/NRPU/R&D/HEC/13/675].
    Year awarded: 2015; year completed: 2018. (Co-PI)
  • Higher Education Commission of Pakistan funded
    project “Nanocrystals (NC) laden enzymatically crosslinked hydrogels for
    accelerated bone tissue regeneration “ amount awarded 4.2 Million for 2022-2025
    (Co-PI)
  • Equipment Grant funded by DAAD (German Academic
    Exchange Service), Germany for the purchase of multimode plate reader „FTIR“
    amount awarded 20000 EURO for 2022.
  • Equipment Grant funded by DAAD (German Academic
    Exchange Service), Germany for the purchase of multimode plate reader „BMG FLUOStar
    Omega“ amount awarded 20000 EURO for 2014.
  •     Higher Education Commission of Pakistan funded
    project “Design, Synthesis and Biological Evaluation of Antagonists of
    Purinergic Receptors (P2X and P2Y): A Novel Approach for the Treatment of
    Inflammation and Neurological Disorders“ amount awarded 12.733 Million for
    2022-2025
  •        Higher Education Commission of Pakistan funded
    project “Targeting NS3-4A Protease:  A
    rational approach for developing New Antivirus against Hepatitis C infection
    based on Medicinally Privileged Heterocyclic scaffolds“ amount awarded 10.0
    Million for 2015-17.
  •          Higher Education Commission of Pakistan funded
    project “Identification and development of P2X selective antagonists derived
    from natural and synthetic sources and their in-silico studies” amount awarded 0.176 Million for 2019-21.
  •    Higher Education Commission of Pakistan funded
    project “Chemical synthesis and elucidation of biological
    effects of fat taste receptor analogues    ” under
    Peridot Research Program     amount awarded 4.9 Million for 2019-22.
  •        CUI funded project “In vitro Evaluation of
    Anti-cancer Effect of Various Ecto-5′-nucleotidase Inhibitors” (Pak Rs 0.3
    Million for 2019).
  •          CUI funded project “Synthesis, In vitro
    Evaluation and Molecular Docking Studies of Selective Inhibitors of Human
    NTPDase3: Role in Type 2 Diabetes.” (Pak Rs 0.3 Million for 2019).
  •     CUI funded project “Development of Assays for
    Dipeptidyl-peptidase 4 Inhibitors as new Antidiabetic Drugs” (Pak Rs 0.3
    Million for 2018).
  •       CUI funded project “Enzyme Inhibition Studies of
    β-Amino acids and their Derivatives” (Pak Rs 0.3 Million for 2018).
  •    Higher Education Commission of Pakistan funded
    project “Provision of Grants to Public Sector Universities and Degree Awarding
    Institutions for Maintenance of Scientific Equipment, HEC” for ‘BMG FLUO StarOmega’.
    amount awarded 1.0 Million for year 2017.
  •          Higher Education Commission of Pakistan funded
    project “Development of potent and selective modulators of alkaline
    phosphatases from natural products as well as synthetic derivatives as lead
    structures“ amount awarded 10.7 Million for 2015-17.
  •     The Organization for the Prohibition of Chemical
    Weapons (OPCW) of Netherlands funded project “Synthesis and Development of NPPs
    inhibitors“ amount awarded 1.2 M for the year 2015-17.
  •         “DAAD German-Pakistani
    Research Collaborations project amount received 20 Million for 2014-15.
  •    Fully Funded Group Study Visit for Group of Foreign Students to Germany  DAAD 2014
  •     Higher Education Commission of Pakistan funded project
    “Provision of Grants to Public Sector Universities and Degree Awarding
    Institutions for Maintenance of Scientific Equipment, HEC” for ‘P/ACE MDQ
    Capillary Electrophoresis’. amount awarded 0.74 Million for year 2014.
  •        “DAAD German-Pakistani
    Research Collaborations project“ amount received 20 Million for 2013-14.
  •     CIIT, Islamabad, “Development of new Antidiabetic Drugs amount received 0.2 Million for
    2012.
  •       CIIT, Islamabad, “Development of drugs for Alzheimer’s Disease Therapy“ amount received 0.2
    Million for 2011.
  •     Higher Education Commission of Pakistan funded
    project “Cloning and Expression of human enzymes in Escherichia Coli, and
    development of high-throughput capillary electrophoresis and Microchip based
    nano scale test system for analysis of inhibitors,, amount awarded 7.065 Million,
    for 2009-10.
  •     COMSTECH-TWAS “Design, synthesis and biochemical
    evaluation of Ecto-5′-Nucleotidase inhibitors as potential anti-tumour agents“
    amount received 1.5 Million, for 2010.
  •      DAAD German-Pakistani
    Research Collaborations project with Prof. Dr. Peter Langer, University of
    Rostock, Germany „Development of Potent and Selective Inhibitors of E-NTPDases“
    amount received 20 Million for 2020-2021.
  •    Pak-France PERIDOT Research Program
    with Prof. Naim Khan, Université de Bourgogne, Dijon, France. “CHEMICAL
    SYNTHESIS AND ELUCIDATION OF BIOLOGICAL EFFECTS OF FAT TASTE RECEPTOR
    ANALOGUES”

 
 
Students Supervised

Supervision of PhD students

S. No.

Name

Year

Thesis title

Status

1

Mr. Shahzad Ahmed

2009

Synthesis of Novel Derivatives of Fluorinated
Pyridines by Palladium Catalyzed Suzuki-Miyaura and Sonogashira Coupling
Reactions

Completed

2

Mr. Khurram Shoaib

2009

Green Synthesis of Fluorinated
Arenes, Benoxazinones and Benzamides

Completed

3

Ms. Rabia Raza

2009

Development and Validation of Analytical
Methods for Screening and Characterization of Enzyme Inhibitors

Completed

4

Ms. Sumera Zaib

2011

Biological Evaluation of Novel Ionic Liquids
and Coordination Complexes

Completed

5

Mr. Hamid Saeed Shah

2012

Synthesis, Characterization and In vitro
Evaluation of Anticancer Potential of Chitosan-coated Polyoxometalates
Nanoparticles

Completed

6

Mr. Azizullah

2013

Development and Evaluation of Self-assembled
Stabilized Supramolecular Hydrogels of Polyoxometalates

Completed

7

Ms. Syeda Abida Ijaz

2013

Identification and Characterization of
Pharmacological Inhibitors of Alkaline Phosphatase Isozymes & Nucleotide
Pyrophosphatase Isozymes

Completed

8

Mr. Mobashir Ali Abid

2013

Synthesis, Biological Investigation and
Molecular Docking Studies of Oxygen Heterocyclic Derivatives as Monoamine
Oxidase Inhibitors

Completed

9

Mr. Shakeel Shah

2013

Assay Optimization and Identification of New
Inhibitors of Acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and
Related Enzymes.

Completed

10

Ms. Sidra Hassan

2014

In vitro Evaluation of Anti-cancer Effect
of Various Ecto-5′-nucleotidase Inhibitors

Completed

11

Faisal Rashid

2014

Synthesis of Acridine and
Acridone Based Thiophene-Sulfonamide Hybrids as Anti-Proliferative Agents

Completed

12

Ms Saira Afzal

2015

Synthesis, In vitro evaluation and Molecular
Docking Studies of Selective Inhibitors of Human NTPDase 3: Role in Type 2
Diabetes

Completed

13

Mr. Aqeel Imran

2016

Synthesis and Characterization of Selective
Inhibitors of Aldose Reductase

Completed

14

Mr. Saif Ullah

2017

Design and Synthesis of
Sulphonate derivatives as Potent Inhibitors of ENPP1

Thesis Submitted

15

Mr. Qasim Shah

2016

Evaluation of Modulatory Effect
of P2X7 Receptor Antagonists in Cancer Cell Survival and Proliferation

Synopsis Approved

16

Mr. Abid Mahmood

2017

Design, Synthesis and Biological Evaluation of Selective Antagonists for P2X Receptors

Completed
         
17 Ms Sehrish Bano 2016 Synthesis and Evaluation of Selective Antagonist of P2Y Receptors Synopsis Approved
18 Sayyad Ali 2021 The Development and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease Completed
19 Mudassir Abbasi 2021 Folate-Modified Nanoparticles Loaded pH-Sensitive Hydrogels to Target Colon Cancer Cells Thesis Submitted
20 Saquib Jalil     Synopsis Approved
21 Muhammad Siraj Khan Jadoon     Synopsis Approved

 

 

Supervision of MS students

S. No.

Name

Year

Thesis title

Status

1

Mr. M. Adil Salman Aslam

2009

Characterization and Structure-Activity
Relationships of Novel Schiff Base Compounds as Potent Inhibitors of Urease
Enzyme

Completed

2

Mr. Mohammad Siraj Khan

2011

Identification of Novel Serine
Protease Inhibitors and Their Implication as a Therapeutic Tool for Various
Diseases

Completed

3

Ms. Javeria Iftikhar

2012

Assay
Development and Characterization of Coumarinyl Oxadiazole and Coumarinyl
Thiourea as Cholinesterase Inhibitors

Completed

4

Mr. Jawad Ali Shah

2013

Identification of Novel Derivatives as Potent
Inhibitors of Cholinesterases, Their Enzyme Kinetics and Molecular Docking
Studies

Completed

 

 

 

 

 

5

Ms. Yildiz Tehseen

2013

Identification and Molecular Modelling
Studies of Novel Coumarinyl Thiazoles and Oxadiazole Derivatives as Selective
and Potent Inhibitors of Aldehyde Reductase

Completed

6

Ms. Syeda Mahwish Bakht

2013

Optimization of Continuous
Spectrophotometric Assay for Monoamine Oxidase-B, Selective Inhibition and Molecular
Modeling Studies

Completed

7

Ms. Naureen Akbar

2014

In Vitro Evaluation of Cytotoxic Potential
and Biological Screening of Novel Metal Complexes

Completed

8

Ms. Zaib un Nisa

2014

 In Vitro and In Silico Screening of Organic compounds against Alkaline Phosphatase and Identification of their Cytotoxic Potential

Completed

     9

Mr. Shafiullah Khan

 

2014

In Vitro and In Silico Evaluation of Sulphonamide Derivatives as Dual
Inhibitors of Carbonic Anhydrase II and 15-Lipoxygenase

Completed

10

Ms. Sundus Sarwar

2014

Nucleotide Pyrophsphatase Inhibition Studies
of Different Fractions of Erythrococca
anomala Seed Extract

Completed

11

Ms. Nehal Afreen Khan

2014

Glucosidase Inhibition Studies of Different
Fractions from Parkia biglibosa Seed
Extract

Completed

12

Mr. Faisal Mukhtar Khan

2015

Exploring the Inhibitory Potential of
Thiourea Derivatives as Carbonic Anhydrase II Inhibitors and Determining
their Mechanism of Action

Completed

13

Ms. Hina
Irum

2015

Determination of Anticancer Mechanism of
Action of Estrone Derivatives

Completed

14

Mr.
Saquib Jalil

2016

Identification and
Bio-Evaluation of Nitrogen Containing Heterocyclic Compounds for Monoamine
Oxidase and ß- amyloid Inhibition Studies

Completed

15

Ms.
Zainab Shafique

2016

Expression and Purification of Carbonic
Anhydrase IX and Identification of its Potential Inhibitors

Completed

16

Ms.
Sayyeda Tayyeba Amjad

2016

Carbonic Anhydrase II expression and
purification followed by in vitro
inhibitor screening

Completed

17

Mr.
Shahid Ullah Khan

2017

 Investigation of Anticancer Potential of Different Fractions of Chrozophora tinctoria

Completed

18

Mr.
Mohammad Uzair

2017

Evaluation of Anticancer Effects of Active
Fractions of Heliotropium calcareum
on Cancer Cell Lines

Completed

19

 

Ms.
Ayesha Basharat

2017

Synthesis, Identification and
Expression Analysis of CD73 Inhibitors in Cervical Cancer

Completed

 
20 Mr. Dilawar Hussain 2018 Structure-based Virtual Screening of Beta Secretase Inhibitors and Their In vitro Analysis Completed
21 Aniqa Bashir 2021 Synthesis, Characterization and Evaluation of Benzene Sulfonamides as Selective Inhibitors of Carbonic Anhydrase II Completed
22 Farooq Ahmad 2022 Synthesis and Evaluation of Benzene Sulfonyl derivatives as P2Y6 Receptor Antagonist Completed

 

Co-supervision of MS
students

S. No.

Name

Year

Thesis title

Status

1

Syed Sher Ali Bukhari

2011

Biological Assays: Implication for the
Prevention of Diabetic Complications

Completed

2

Mr. M. Azhar Hayat Nawaz

2011

Phytochemical Investigation and
Biological Activities of Chemical Constituents of Oleaferruginea

Completed

3

Mr. Shoaib Iqbal

2011

Characterization of Potential
Anti-Diabetic and Anti-Alzheimer’s Compounds using Capillary Electrophoresis
based Enzyme Assays

Completed

4

Ms. Mehwish Humayun

2011

Discovery of new benzene
sulphonamide derivatives as potent inhibitors of bovine cytosolic carbonic
anhydrase

Completed

5

Mr. Aqeel Imran

2012

Investigation
of New Schiff Base Derivatives as Potential Urease Inhibitors

Completed

6

Mr. Sarfraz Ahmad

2012

Monitoring of Antidepressant Drugs in Human
Plasma by Using Capillary Electrophoresis Technique

Completed

7

Ms. Saba Abbas

2012

In Vivo Method for Monitoring of Antiepileptic
Drugs in Human Plasma Using Capillary Zone Electrophoresis

Completed

8

Ms Zaitoon Ilyas

2013

Patient knowledge about hypertension and
quality of life and acceptance of illness: a comparison between hypertensive
patients with and without comorbidities

Completed

9

Mr. Lateef Ullah

2016

Screening of Breast Cancer patients for some
BRCA2 Gene Mutation

Completed

10

Mr. Shafiq Ur Rahman

2016

Structure-based Virtual Screening of
Dipeptidyl Peptidase IV Inhibitors and Their In vitro Analysis

Completed

 

11

Ms. Kiran Hamid

2021

Synthesis, Biological
Evaluation and Molecular Docking Studies of Novel Benzene Sulphonates
Derivatives as Nucleotide
Pyrophosphatases/Phosphodiesterases (NPP) Inhibitors

Completed

12

Ms. Amina Batool

2021

 Synthesis and Biological Evaluation of Novel Heteroaryl Sulphonamides as Pyrophosphatases/Phosphodiesterases (NPP) Inhibitors

 

Completed

 

13

Natasha Anwar  

 

2022

 Synthesis and Biological Evaluation of Novel Heteroaryl Sulphonamides

Completed

 

14

Hadia Malik

 

2022

Design, Synthesis and Anticancer Studies of Novel
Nitrogen Containing Heterocycles

 

Completed

 

15

Muhammad Amir Mehtab 

 

2022

Synthesis and Biological Evaluation of Sulphonamide Derivatives as
Inhibitors of Carbonic Anhydrase.

Completed

 

16

Faryal Azeem

2023

Anti-cancer Evaluation and Molecular Docking Studies of Sulfonylurea
and Sulfonylthiourea Derivatives

Completed

 

17

18

 

20

Farah Jabeen

 Aqsa Jabeen

 

Fatima Sikandar 

2022

2023

 

2023

 

 

Drug Discovery By Using Machine Learning Techniques

Anticancer
activities of novel 1, 3, 4-oxadiazoles and quinoline derivatives

Enzyme inhibition activities of substituted amides

 

Completed

Completed

 

Completed