Synthetic Organic Chemistry

1. Facile Synthesis Of Substituted Carbohydrazide Building Blocks

Carbohydrazide derivatives are known to be antimalarial, antitubercular, antitumor, agonist and anticancer agents. Keeping in view their potential utility, we want to synthesize novel building blocks of substituted carbohydrazide. Such building blocks can be incorporated in various biologically active molecules also in some secondary structures of proteins (beta-sheets). As these building blocks can mimic the donor acceptor behavior of naturally occurring peptides, they can potentially play significant role in the folding pattern of secondary structures of proteins. A facile synthetic route for the synthesis of this substituted carbohydrazide building blocks will be optimized and the key intermediates will be fully characterized using various analytical techniques like IR, NMR, and HRMS.


Project Funding
 Funding Body Funds
1 HEC no logo 0.5 Million Rupee


Project Members
  • Dr. Farhan A.  Khan
  • Dr. Muhammad  Arshad
  • 2. Synthesis, Characterization And UV Studies Of The Coumarin Substituted Triazoles, Oxadiazoles And Pyrazoles

    coumarins are natural fluorophores are used as light emitting diodes. On the other hand Oxadiazoles, Triazoles and pyrazoles are also known for their florescence activities  can be used as detectors etc. In view of their industrial and medicinaly significance the aim and objective of the present research is to synthesized some coumarin substituted Oxadiazoles, tiazoles and pyrazoles and check them for their UV studies.


    Project Funding
     Funding Body Funds
    1 HEC no logo 0.5 Rs


    Project Members
  • Dr. Amara  Mumtaz
  • 3. Synthesis, Characterizaterization And Biological Activities Of Five Membered Heterocycles.

    Project describes the synthesis of some five membered heterocycles starting from their common precursor hydrazides some 1,3,4-Oxadiazoles, 1,2,4-triazoles and 3,5-disubstituted pyrazoles will be synthesized and then will be subjected to their biological activities. Structures of all the synthesized compounds will be conform by using IR, 1HNMR, 13CNMR and Mass analysis


    Project Funding
     Funding Body Funds
    1 CIIT no logo 0.2 Rs


    Project Members
  • Dr. Amara  Mumtaz
  • 4. Synthesis And Photocatalyticc Properties Of Titanium Phthacyanines Axially Substituted With Tetracyanoquinodimethane And Its Derivatives

    Synthesis and photophysical of substituted titanium phthalocyanines containing tetracyanoquinodimethane (TCNQ) and its derivatives at axial position, capable of absorbing at longer wavelengths with high molecular extinction coefficient. The photophysical chareacterization of synthesized Pcs by means of steady state and time resolved photophysical techniques, will be accomplished to evaluate the applications of synthesized compounds in dye sensitized solar cells.


    Project Funding
     Funding Body Funds
    1 HEC no logo 500000 Rs


    Project Members
  • Dr. Farhan A.  Khan
  • Dr. Zafar Iqbal
  • 5. A Facile Enantioselective Synthesis Of (+)-(R)-Concentricolide (A Natural Alkaloid)”

    A Facile Enantioselective Synthesis of (+)-(R)-Concentricolide (A Natural Alkaloid).


    Project Funding
     Funding Body Funds
    1 PSF no logo 2.07 Million Rupee


    Project Members
  • Dr. Adeem Mahmood
  • 6. Structure Identification Of Microbial Metabolites Department Of Organic And Bimolecular Chemistry,

    Chemical investigation of the terrestrial  Streptomyces  sp. isolates GT2005/020 and ANK148 led to the isolation of  two microbial furanone derivatives,  5-hydroxy-4-methylnaphtho[1,2-b]furan-3-one (1) and 4-hydroxy-5-methyl-furan-3-one (2), respectively, which have some similarity to quorum sensing molecules of the AI-2 type. In addition, the known compounds chalcomycin, ferulic acid, indole-3-acetic acid, uracil, thymine, 2'-deoxy-thymidin, monensin B (3), phencomycin, and 1-acetyl-β-carboline were isolated. The structures of 1 and 2 were deduced from extensive studies of NMR (1D and 2D) and mass 
    spectra. Additionally, the complete NMR shift assignments for monensin B (3) using H-H COSY, HMQC and HMBC experiments are reported here for the first time. We are describing the taxonomy and fermentation of the producing strains, the structure elucidation of the new metabolites and their bioactivity. 

    Project Funding
     Funding Body Funds
    1 HEC and University of Gottingen, Germany no logo 3000 $


    Project Members
  • Dr. Muhammad  Arfan
  • 7. Modified Activity Of Commercially Available Antibiotic Drugs By Making Gold Nano-Particle Conjugates.

    In the fast-developing field of nanotechnology, gold nanoparticles (Au-NPs) have served as a versatile platform for exploring many facets of basic science. Conjugation of Au-NPswith oligosaccharide, DNA, proteins, or small bio-functional molecules also find applications in biology.


    Project Funding
     Funding Body Funds
    1 CIIT no logo 175000 Rs


    Project Members
  • Dr. Ahson Jabbar Shaikh
  • Dr. Farhan A.  Khan
  • 8. Synthesis Of Biologically Active Coumarin Derivatives By Palladium Catalysed Cross Coupling Reaction

    Synthesis of Biologically Active Coumarin Derivatives by Palladium Catalysed Cross Coupling Reaction


    Project Funding
     Funding Body Funds
    1 CIIT no logo 175000 Rs


    Project Members
  • Dr. Farhan A.  Khan
  • 9. Design, Synthesis And Characterization Of Biologically Active Coumarine Derivatives

    Hydrazones and their metal complexes posses’ wide spectrum of pharmacological analytical, magnetic and optical applications. Hydrazones and their metal complexes are being used against various pathogens; therefore, synthesized hydrazones and their metal complexes can be potentially active and will be fully Characterized using different modern instrumental techniques such elemental analysis (C.H.N.),1H NMR, 13C NMR, FTIR, UV/Visible spectroscopy, magnetic susceptibility, X-Ray crystallography, thermogravimetric analysis (TGA) and fluorescence properties. Synthesized compounds will also be screened for their pharmacological potential against various pathogenic strains i.e. bacterial and fungal strains.


    Project Funding
     Funding Body Funds
    1 CIIT no logo 190000 Rs


    Project Members
  • Dr. Farhan A.  Khan
  • 10. Synthesis And Antibacterial Efficiency Of Heterocyclic Substituted Quinolone Carboxylic Acids.

    With the increase in antibacterial drug development resistance of bacteria against the antibacterial drugs is increasing day by day. This problem has triggered the attention of the scientists to introduce new antibacterial drugs. Carboxylic acid substituted Quinolone derivatives are famous for their broad spectrum activities as antimicrobial agents. They are active against the both gram negative bacteria as well as gram positive strains of bacteria. The current project is about the synthesis of some quinolone carboxylic acid substituted oxadiazole, triazoles and triazole amine starting from their common precursor hydrazides. Structures of all the synthesized compounds will be confirmed by IR, 1HNMR,13CNMR spectral analysis. As literature reveals the antibacterial significance of the quinolone carboxylic acids, all the synthesized compounds will subjected to their antibacterial assays against the gram positive and gram negative strains of bacteria.


    Project Funding
     Funding Body Funds
    1 HEC no logo 365000 Rs


    Project Members
  • Dr Asma  Zaidi
  • Dr. Syed Majid Bukhari
  • 11. Design, Synthesis And Characterization Of 4-Aminoantipyrine Derivatives

    Synthesis of 4-aminoantipyrine based Schiff Bases and their metal complexes are of interest due to their potential as biologically active molecules. Schiff bases and metal complexes are currently used against various pathogens; therefore, synthesized ligands and their metal complexes can be potentially active and will be fully characterized using different modern instrumental techniques such elemental analysis (C.H.N.), 1HNMR, 13CNMR, FTIR,UV/Visible spectroscopy, magnetic susceptibility, X-Ray crystallography, thermal studies and fluorescence properties. Synthesized compounds will also be screened for their pharmacological potential against various pathogenic strains i.e. bacterial and fungal strains.


    Project Funding
     Funding Body Funds
    1 CRGP no logo 190000 Rs


    Project Members
  • Dr Asma  Zaidi
  • Dr. Farhan A.  Khan
  • 12. Design, Syntheses, Development Of Next Generation Low Cost Angiogenesis Inhibitors And Potential Anticancer Agents"

    Thymidine phosphorylase (TP) contributes in the promotion of an angiogenic activity and identical to platelet derived endothelial cell growth factor (PD-ECGF). Large production of TP is found in several tumors and contributes a vital part in the development of angiogenesis, progression of tumor, incursion and metastasis. The balanced enzymatic activity of thymidine phosphorylase is vital to induce beneficial angiogenesis. Factors responsible for tumor growth stimulate undesired proangiogenic activity and become unable to maintain tight equilibrium between proangiogenic and antiangiogenic activity. The end product of degraded thymidine phosphorylase is 2-deoxy-D-ribose. This monosaccharide (2-deoxy-D-ribose) is believed to stimulate unwished angiogenesis, migration of abnormal cells, increase in tumor size and metastasis. At the moment, we believe that there is considerable space for the development of potent angiogenesis inhibitors and TP inhibitor because they may act as next generation promising anticancer agents.
    Project Members
  • Dr. Sohail Anjum Shahzad
  • 13. Development Of Next-Generation Explosives Sensing Technology And Key Products Based On Unique Fluorescent Materials

    Fluorescence-based analytical tools are becoming very attractive for rapid detection of explosives. Fluorescence emission is very sensitive phenomena and any change in fluorescence emission can be observed upon interactions of fluorescence probes with analytes present in the explosives. Explosive molecules are extremely electron deficient materials due to the presence of electron withdrawing groups such as nitro group. Such electron deficient molecules can easily interact and bind with electron-rich fluorescent molecules (fluorophors). Fluorescence of a fluorphore can be quenched through molecular interactions between the fluorophore and specific explosive material. The oxidation and reduction potentials would predict the direction of electron flow. Energy of ground state orbitals and excited state orbitals would also predict the direction of photo-induced electron transfer. With this in mind, π-electron rich tetraphenyethylene and fluorene-based conjugated polymers are designed. Electron rich conjugated polymers will provide basis for contact with electro-deficient explosive molecules through the donor-acceptor (D-A) interactions. A conjugated polymer with fluorene backbone and phenylene as spacer units is designed for rapid detection of ultra-trace analytes from explosive molecules. Sterically large adamantane group and pyrene moiety will serve as bulky side chains which will impart desired properties to the proposed polymers. A library of relevant fluorescent polymers will be generated by varying size of side chains.


    Project Funding
     Funding Body Funds
    1 PSF of Pakistan and NSFC China no logo 4958118 Rs


    Project Members
  • Dr. Sohail Anjum Shahzad
  • 14. Synthesis Of Biologically Active Benzofurans And Dihydropyrimidines And Evaluation Of Their Biological Activity

    The wide-ranging and potent activity of benzofuran has recognized as one of the biological important scaffold. This project is covered the methods for the synthesis of benzofurans and its related heterocycles, structure activity relationship and pharmacological activities. It is an effort to highlight the significance of the benzofuran in the present perspective and promise they hold for the future. The project will focus on using substituted alkenes as substrates for generating heterocycles such as dihydropyrimidines and benzofurans. An activation of substituted alkenes with selenium and palladium reagents will give rise to either cyclic compounds or desired functionalization of alkenes. This study will represent our initial effort toward the synthesis of benzofurans and dihydropyrimidines. Once an initial method has been identified, a variety of substrates have to be undertaken in order to bring the desired synthesis to useful levels.

    Project Members
  • Dr. Sohail Anjum Shahzad
  • 15. Synthesis And Application Of Antimicrobial Additives In Paint And Paint-Film

    In present research, various ligands are planned from commercially available chemicals. Treatment of substituted benzonitriles with hydroxylamine hydrochloride in the presence of sodium carbonate using ethanol / methanol as solvents will furnish N-hydroxybenzamidines in good yields. Upon further treatment of N-hydroxybenzamidines with various transitions metals under appropriate reaction conditions, a library of target metal complexes was obtained in good yields. After getting encouraging results from metal complexation of benzamidines, another type of organic ligand for example chalcone will also considered to prepare diverse range of metal complexes. For this purpose, various substituted chalcones were formed by treating different acetophenone with suitable benzaldehydes under mild and basic reaction conditions. Furthermore, reaction of various metal (II) chlorides / nitrates with various analogues of chalcones under reflux reaction conditions will provide new metal complexes in good yields. Finally, detailed chemical structures of synthesized compounds were characterized through spectroscopic methods such as FTIR, 1H NMR and 13C NMR spectroscopy. Their role in paint will be studied as a antibacterial materials.

    Project Members
  • Dr. Sohail Anjum Shahzad